{"id":4153,"date":"2024-05-16T09:18:06","date_gmt":"2024-05-16T07:18:06","guid":{"rendered":"https:\/\/blog.uchceu.es\/medicina\/?p=4153"},"modified":"2024-05-16T09:18:08","modified_gmt":"2024-05-16T07:18:08","slug":"lipid-particles-and-their-roles","status":"publish","type":"post","link":"https:\/\/blog.uchceu.es\/medicina\/en\/lipid-particles-and-their-roles\/","title":{"rendered":"Lipid particles and their roles"},"content":{"rendered":"\n<p>Lipoproteins are considered complex molecules that have a central core that contains cholesterol esters and triglycerides, which in turn are surrounded by free cholesterol, phospholipids, and apoliproteins. Their functions include: absorption and transport of dietary lipids and transport of toxic foreign compounds. A lipoprotein is an assembly of both lipids and proteins, hence the name and are classified based on their <strong>DENSITY<\/strong>. Because lipids are <strong>LIGHTER<\/strong> than proteins, particles that contain more lipids are <strong>LARGER<\/strong> in size but have <strong>LOWER<\/strong> density and those containing more proteins are <strong>SMALLER<\/strong> in size but have <strong>HIGHER<\/strong> density.<\/p>\n\n\n\n<p>Although it has gained a <strong>BAD<\/strong> reputation as a high-risk factor for cardiovascular diseases, cholesterol is an <strong>ESSENTIAL<\/strong> component of all animal cells. And amongst other numerous cellular processes it provides cell membrane <strong>FLUIDITY<\/strong>, serves as a <strong>PRECURSOR<\/strong> for the production of bile, steroid hormones, and vitamin D. Its synthesis can be both endogenous (regulated via a negative feedback mechanism) or obtain cholesterol from food. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"650\" height=\"484\" src=\"https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-650x484.png\" alt=\"\" class=\"wp-image-4156\" srcset=\"https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-650x484.png 650w, https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-315x235.png 315w, https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-768x572.png 768w, https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-1536x1145.png 1536w, https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-485x360.png 485w, https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-696x519.png 696w, https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-1068x796.png 1068w, https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-564x420.png 564w, https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-80x60.png 80w, https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2-265x198.png 265w, https:\/\/blog.uchceu.es\/medicina\/wp-content\/uploads\/sites\/25\/2024\/05\/image-2.png 1814w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/figure>\n\n\n\n<p>Lipids are classified by the main features and properties of the different lipid particles, going from the smallest in size, <strong>HDL<\/strong> to the largest one, Chylomicrons. Thus, HDL is the smallest of the group ( 5-12nm), it works to take cholesterol from tissues to the liver and has important positive functions in our body as it is an anti-atherogenic, anti-oxidant\/inflammatory\/thrombotic\/apoptotic. <strong>LDL<\/strong> Is mainly made of cholesterol and Apo B-100, and it works to carry most of the cholesterol in circulation and small dense LDL. <strong>IDL<\/strong> is comprised of triglycerides and cholesterol. And like LDL and <strong>VLDL<\/strong> its major Apolipoproteins are: <strong>Apo B-100<\/strong> (and also <strong>Apo-E<\/strong> and <strong>Apo-C<\/strong>). It is mainly pro-atherogenic which means that it works in the formation of atherosclerosis plaques in the vessels. VLDL is a transporter for triglycerides and is also pro-atherogenic. Finally, <strong>Chylomicrons<\/strong>. It is the biggest lipoprotein, it transports dietary TGs and cholesterol to peripheral tissues and liver for the cycle to begin again (<strong>Figure<\/strong>).<\/p>\n\n\n\n<p>To conclude, there is a variety of lipid particles in our system with different functions. Some are seen as \u201cbad\u201d like VLDL as they contain more lipids and thus are pro-atherogenic; while others like HDL are considered \u201cgood\u201d and have anti-inflammatory purposes amongst other functions.<\/p>\n\n\n\n<p><strong>By Valentina Frias, Osmaida Zumbi, Fatim-Zahra Tanji &amp; Luis D&#8217;Marco <\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lipoproteins are considered complex molecules that have a central core that contains cholesterol esters and triglycerides, which in turn are surrounded by free cholesterol, phospholipids, and apoliproteins. Their functions include: absorption and transport of dietary lipids and transport of toxic foreign compounds. A lipoprotein is an assembly of both lipids and proteins, hence the name [&hellip;]<\/p>\n","protected":false},"author":579,"featured_media":4156,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[246,244],"tags":[],"class_list":["post-4153","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-information-of-interest","category-study-tips"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lipid particles and their roles<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.uchceu.es\/medicina\/en\/lipid-particles-and-their-roles\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lipid particles and their roles\" \/>\n<meta property=\"og:description\" content=\"Lipoproteins are considered complex molecules that have a central core that contains cholesterol esters and triglycerides, which in turn are surrounded by free cholesterol, phospholipids, and apoliproteins. Their functions include: absorption and transport of dietary lipids and transport of toxic foreign compounds. 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