Enfermedad de Alzheimer<\/a>.<\/p>\n\n\n\nResultados preliminares<\/h3>\n\n\n\n El estudio \u201cClarity\u201d, es un ensayo cl\u00ednico en fase III que se ha dirigido a comprobar si lecanemab podr\u00eda modificar el curso del Alzheimer. Durante 18 meses, cerca de 1800 personas que sufr\u00edan de deterioro cognitivo leve o fase leve de demencia producida por la Enfermedad de Alzheimer fueron evaluados en este estudio controlado de doble ciego. A cada persona se le administraron 10 mg\/kg del producto en investigaci\u00f3n cada dos semanas. Los participantes fueron asignados en una proporci\u00f3n de 1:1 para recibir placebo o lecanemab. Al finalizar el ensayo, se ha observado como las personas que recibieron el f\u00e1rmaco disminuyeron hasta un 27% la progresi\u00f3n cl\u00ednica de la enfermedad del Alzheimer.<\/p>\n\n\n\n
En la fase III de un ensayo cl\u00ednico se asegura que el f\u00e1rmaco sea efectivo<\/strong> y seguro<\/strong>. En este tipo de estudios participan entre 1.000 y 5.000 pacientes voluntarios. Por otro lado, en los estudios controlados de doble ciego ni el m\u00e9dico ni el paciente saben qui\u00e9n est\u00e1 recibiendo el f\u00e1rmaco en investigaci\u00f3n y quien est\u00e1 recibiendo el placebo.<\/p>\n\n\n\n<\/p>\n\n\n\n
Direcciones futuras<\/h3>\n\n\n\n
Investigadores internacionales creen que los resultados de este ensayo son esperanzadores y afirman que es la primera vez que hay un ensayo con resultados claramente positivos para frenar el deterioro. No obstante, han aparecido efectos adversos como anticuerpos antiamieloide, micro y macrohemorragias cerebrales y sintomatolog\u00eda ARIA, siendo este \u00faltimo efecto adverso caracter\u00edstico de los f\u00e1rmacos antiamiloides.<\/p>\n\n\n\n
En conclusi\u00f3n, aunque este f\u00e1rmaco sigue sin poder curar la Enfermedad del Alzheimer, podr\u00eda retrasar hasta un 27% el deterioro cl\u00ednico. Adem\u00e1s, este ensayo ha suscitado grandes esperanzas en millones de pacientes que hay en el mundo con esta enfermedad neurodegenerativa, pretendi\u00e9ndose solicitar la aprobaci\u00f3n del f\u00e1rmaco en EE.UU., Jap\u00f3n y Europa antes de marzo de 2023.<\/p>\n\n\n\n
<\/p>\n\n\n\n
Art\u00edculo realizado por Claudia Rovira Yago, alumna interna en Farmacolog\u00eda y Farmacia Cl\u00ednica del grado en Farmacia en la Universidd CEU-Cardenal Herrera. Revisado por Gemma Garcia Lluch, doctoranda en CEINDO.<\/p>\n","protected":false},"excerpt":{"rendered":"
Lecanemab es un f\u00e1rmaco antiamiloide que podr\u00eda retrasar el avance de la Enfermedad de Alzheimer en un 27%<\/p>\n","protected":false},"author":542,"featured_media":54962,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[261,390,282,35,45,389],"class_list":{"0":"post-54961","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-divulgacion-cientifica","8":"tag-catedra-deco","9":"tag-deterioro-cognitvo","10":"tag-enfermedad-de-alzheimer","11":"tag-farmacologia","12":"tag-investigacion","13":"tag-lecanemab"},"yoast_head":"\n
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