{"id":1465,"date":"2014-04-16T16:31:30","date_gmt":"2014-04-16T14:31:30","guid":{"rendered":"https:\/\/blog.uchceu.es\/farmacia\/?p=1465"},"modified":"2017-11-28T15:31:35","modified_gmt":"2017-11-28T14:31:35","slug":"captopril-el-primer-caso-de-diseno-racional-de-un-farmaco","status":"publish","type":"post","link":"https:\/\/blog.uchceu.es\/farmacia\/captopril-el-primer-caso-de-diseno-racional-de-un-farmaco\/","title":{"rendered":"Captopril, el primer caso de dise\u00f1o racional de un f\u00e1rmaco."},"content":{"rendered":"<p><a href=\"https:\/\/blog.uchceu.es\/farmacia\/wp-content\/uploads\/sites\/5\/2014\/04\/lourdes.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-1466\" alt=\"lourdes\" src=\"https:\/\/blog.uchceu.es\/farmacia\/wp-content\/uploads\/sites\/5\/2014\/04\/lourdes.png\" width=\"203\" height=\"251\" \/><\/a><\/p>\n<p>Siguiendo con los res\u00famenes de los art\u00edculos de nuestros alumnos encontramos el realizado por Lourdes Morro Felipe, en el cual nos cuenta la historia racional del captopril, un inhibidor de la enzima de conversi\u00f3n de la angiotensina (IECA). La historia de este f\u00e1rmaco es inversa a la mayor\u00eda de los dem\u00e1s ya que una vez conocida la estructura y funcionamiento del sistema renina-angiotensina se encontr\u00f3 una diana y se dise\u00f1\u00f3 una estructura capaz de interaccionar con ella. Todo ello empez\u00f3 a finales del siglo XIX cuando se descubri\u00f3 que la hipertensi\u00f3n estaba vinculada con el sistema renina-angiotensina-aldosterona. A partir de aqu\u00ed se investig\u00f3 dicho sistema y se descubri\u00f3 que la angiotensina, polip\u00e9ptido que aumenta la presi\u00f3n arterial, se produc\u00eda en dos etapas y el objetivo de las investigaciones se centr\u00f3 en la enzima que transformaba el polip\u00e9ptido de inactivo a activo. Es aqu\u00ed donde destac\u00f3 Mauricio Rocha e Silva, qui\u00e9n empez\u00f3 a hacer pruebas con gotas de veneno de la Bothrops Jararaca Jaracussa, v\u00edbora que provocaba la muerte por una bajada de presi\u00f3n producida, ya que conten\u00eda un p\u00e9ptido bioactivo hipotensivo denominado bradicinina, consecuencia de su acci\u00f3n inhibidora de la degradaci\u00f3n de la enzima. Cient\u00edficos del grupo del Dr. Vane descubrieron que los extractos tambi\u00e9n inhib\u00edan la conversi\u00f3n de angiotensina I (inactiva) a angiotensina II (activa).<\/p>\n<p>Tras muchas m\u00e1s investigaciones se lleg\u00f3 a la concusi\u00f3n que tanto la bradicinina como la angiotensina I eran sustratos de dicha enzima (ECA). A partir de aqu\u00ed se empez\u00f3 a dise\u00f1ar la estructura del receptor de la ECA y a partir de ello desarrollar un f\u00e1rmaco capaz de inhibirla. Despu\u00e9s de varios f\u00e1rmacos se lleg\u00f3 al captopril, el m\u00e1s activo como antihipertensivo. Si quieres saber m\u00e1s detalles sobre la historia del captopril solo debes leer\u00a0el art\u00edculo completo.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Siguiendo con los res\u00famenes de los art\u00edculos de nuestros alumnos encontramos el realizado por Lourdes Morro Felipe, en el cual nos cuenta la historia racional del captopril, un inhibidor de la enzima de conversi\u00f3n de la angiotensina (IECA). La historia de este f\u00e1rmaco es inversa a la mayor\u00eda de los dem\u00e1s ya que una vez [&hellip;]<\/p>\n","protected":false},"author":58,"featured_media":1466,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[83,35,41],"class_list":{"0":"post-1465","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-nuestros-alumnos","8":"tag-farmaceutico-joven","9":"tag-farmacologia","10":"tag-historias-de-medicamentos"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Captopril, el primer caso de dise\u00f1o racional de un f\u00e1rmaco.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.uchceu.es\/farmacia\/captopril-el-primer-caso-de-diseno-racional-de-un-farmaco\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Captopril, el primer caso de dise\u00f1o racional de un f\u00e1rmaco.\" \/>\n<meta property=\"og:description\" content=\"Siguiendo con los res\u00famenes de los art\u00edculos de nuestros alumnos encontramos el realizado por Lourdes Morro Felipe, en el cual nos cuenta la historia racional del captopril, un inhibidor de la enzima de conversi\u00f3n de la angiotensina (IECA). La historia de este f\u00e1rmaco es inversa a la mayor\u00eda de los dem\u00e1s ya que una vez [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blog.uchceu.es\/farmacia\/captopril-el-primer-caso-de-diseno-racional-de-un-farmaco\/\" \/>\n<meta property=\"og:site_name\" content=\"Blog de Farmacia\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/FarmaciaUCH\" \/>\n<meta property=\"article:published_time\" content=\"2014-04-16T14:31:30+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2017-11-28T14:31:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blog.uchceu.es\/farmacia\/wp-content\/uploads\/sites\/5\/2014\/04\/lourdes.png\" \/>\n\t<meta property=\"og:image:width\" content=\"203\" \/>\n\t<meta property=\"og:image:height\" content=\"251\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Lucrecia Moreno\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lucrecia Moreno\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/blog.uchceu.es\/farmacia\/captopril-el-primer-caso-de-diseno-racional-de-un-farmaco\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/blog.uchceu.es\/farmacia\/captopril-el-primer-caso-de-diseno-racional-de-un-farmaco\/\"},\"author\":{\"name\":\"Lucrecia Moreno\",\"@id\":\"https:\/\/blog.uchceu.es\/farmacia\/en\/#\/schema\/person\/154c662e362d40f063722d729b51e888\"},\"headline\":\"Captopril, el primer caso de dise\u00f1o racional de un 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