{"id":869,"date":"2011-10-25T10:59:35","date_gmt":"2011-10-25T10:59:35","guid":{"rendered":"https:\/\/blog.uchceu.es\/eponimos-cientificos\/?p=869"},"modified":"2021-05-28T13:34:58","modified_gmt":"2021-05-28T11:34:58","slug":"reaccion-solucion-de-dakin","status":"publish","type":"post","link":"https:\/\/blog.uchceu.es\/eponimos-cientificos\/reaccion-solucion-de-dakin\/","title":{"rendered":"REACCI\u00d3N, SOLUCI\u00d3N DE DAKIN"},"content":{"rendered":"

HENRY DRYSDALE DAKIN (1880-1952)<\/strong>
\nJos\u00e9 Mar\u00eda de Jaime Lor\u00e9n (2010)<\/p>\n

 <\/p>\n

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Datos biogra\u0301ficos<\/strong><\/p>\n

Qui\u0301mico ingle\u0301s que era el menor en una familia de ocho hijos dedicada al comercio de productos sideru\u0301rgicos de Leeds, en cuya Universidad estudio\u0301 qui\u0301mica con Julius B. Cohen, doctora\u0301ndose con una tesis sobre aminoa\u0301cidos. Paso\u0301 despue\u0301s a investigar sobre la arginasa junto a Al- brecht Kossel en la Universisad de Heidelbert, de donde paso\u0301 a la de Columbia en Estados Unidos el an\u0303o 1905 para trabajar en el laboratorio de Christian Herter.<\/p>\n

En 1914 regreso\u0301 a Inglaterra ofreciendo sus servicios du- rante la Primera Guerra Mundial, atendiendo entonces la solicitud del qui\u0301mico Alexis Carrel del Instituto Rockefe- ller, con el que empezo\u0301 a colaborar en 1916 en un hospital de campan\u0303a en Compe\u0300gne. Alli\u0301 desarrollari\u0301an ambos el me\u0301todo Dakin-Carrel de tratamientos de heridas de guerra con la solucio\u0301n de su nombre.<\/p>\n<\/div>\n

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Al concluir la guerra volvio\u0301 a Estados Unidos donde se caso\u0301 y reanudo\u0301 sus investigaciones en su propio laboratorio en Scarsdale (Nueva York), colaborando estrechamente con otros cienti\u0301ficos sobre aminoa\u0301cidos y enzimas. Se le atribuye la invencio\u0301n de la extraccio\u0301n de aminoa\u0301cidos de los pe\u0301ptidos hidrolizados por butanol. Igualmente se intere- so\u0301 por otros campos de la qui\u0301mica orga\u0301nica, asi\u0301 como del descubrimiento de la reaccio\u0301n Dakin.<\/p>\n

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Reaccio\u0301n de Dakin<\/strong><\/p>\n

Se trata de una reaccio\u0301n qui\u0301mica de aldehi\u0301dos feno\u0301licos o cetonas con pero\u0301xido de hidro\u0301geno, de la que se obtienen bifenoles y a\u0301cido carboxi\u0301lico. No debe confundirse con la Reaccio\u0301n de Dakin-Oeste que es distinta.<\/p>\n

Solucio\u0301n de Dakin<\/strong><\/p>\n

El te\u0301rmino solucio\u0301n en farmacia puede considerarse equi- valente al de disolucio\u0301n, que corresponde a cualquiera de las numerosas formas farmace\u0301uticas en las que un o varios solutos, generalmente los principios activos, se disuelven en los disolventes habituales (agua, alcohol, e\u0301ter, glicerina, cloroformo, sulfuro de carbono, hidrocarburos li\u0301quidos, vino, cerveza, vinagre o aceites).<\/p>\n

Junto al cirujano france\u0301s Alexis Carrel (1873-1944), Henry H. Dakin obtuvo la Cloramina, antise\u0301ptico utilizado como Solucio\u0301n Dakin en los campos de batalla con gran e\u0301xito. Ma\u0301s tarde comercializada por los laboratorios Abbott con el nombre de Chloraze\u0300ne.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Se trata de una solucio\u0301n muy diluida de hipoclorito de sodio al 0\u20194 o\u0301 0\u20195 % y a\u0301cido bo\u0301rico al 4 %. La solucio\u0301n es bastante inestable y se deteriora en pocos di\u0301as, por lo que se introdujeron modificaciones para mejorar su estabilidad. Posteriormente la solucio\u0301n seri\u0301a comercializada por distin- tos laboratorios. Se ha utilizado como anti-infeccioso por vi\u0301a to\u0301pica en piel y heridas.<\/p>\n

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Bibliografi\u0301a<\/strong><\/p>\n

KING, M.W. (2008): Nuestras rai\u0301ces histo\u0301ricas: Dakin y su solucio\u0301n. Herida de Ostomi\u0301a Enfermeri\u0301a Continencia (WOCN), 35 (3), 289-292
\nPERCIVAL HARTLEY (1952): Henry Drysdale Dakin. 1880-1952. Obituarios de los becarios de la Real Socie- dad, 8 (21), 128-148. En 10.1098\/rsbm.1952.0009 . http:\/\/links.jstor.org \/ SICI? SICI 1479-571X = (195,211) 8% 3A21% 3C128% 3AHDD1% 3B2% 3E2.0.CO-K Con- sulta: 27 de julio de 2010<\/p>\n

REZAYAT, C.; WIDMANN, W.H. (1952): Henry Drysda- le Dakin: Mucho ma\u0301s que su solucio\u0301n. Cirugi\u0301a actual, 63 (3), 194-196. En 10.1098\/rsbm.1952.0009 . http:\/\/links.jstor.org \/ SICI? SICI 1479-571X = (195,211) 8% 3A21% 3C128% 3AHDD1% 3B2% 3E2.0.CO-K Con- sulta: 27 de julio de 2010<\/p>\n

Jose\u0301 Mari\u0301a de Jaime Lore\u0301n<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

HENRY DRYSDALE DAKIN (1880-1952) Jos\u00e9 Mar\u00eda de Jaime Lor\u00e9n (2010)   Datos biogra\u0301ficos Qui\u0301mico ingle\u0301s que era el menor en una familia de ocho hijos dedicada al comercio de productos sideru\u0301rgicos de Leeds, en cuya Universidad estudio\u0301 qui\u0301mica con Julius B. Cohen, doctora\u0301ndose con una tesis sobre aminoa\u0301cidos. Paso\u0301 despue\u0301s a investigar sobre la arginasa […]<\/p>\n","protected":false},"author":173,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[485,486],"class_list":{"0":"post-869","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-medicos","7":"tag-dakin","8":"tag-henry-drysdale"},"yoast_head":"\nREACCI\u00d3N, SOLUCI\u00d3N DE DAKIN - Ep\u00f3nimos Cient\u00edficos | Universidad CEU Cardenal Herrera<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.uchceu.es\/eponimos-cientificos\/reaccion-solucion-de-dakin\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"REACCI\u00d3N, SOLUCI\u00d3N DE DAKIN - Ep\u00f3nimos Cient\u00edficos | Universidad CEU Cardenal Herrera\" \/>\n<meta property=\"og:description\" content=\"HENRY DRYSDALE DAKIN (1880-1952) Jos\u00e9 Mar\u00eda de Jaime Lor\u00e9n (2010)   Datos biogra\u0301ficos Qui\u0301mico ingle\u0301s que era el menor en una familia de ocho hijos dedicada al comercio de productos sideru\u0301rgicos de Leeds, en cuya Universidad estudio\u0301 qui\u0301mica con Julius B. 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